Historical Perspective of PRRS Area Regional Control (PRRS ARC) – PRV What Lessons Apply to PRRSv Control and Elimination? - Dr. Joe Connor, Carthage Vet Service, from the 2014 North American PRRS Symposium, December 5-6, 2014, Chicago, IL, USA.
Quicker Detection Needed Dr. Jeff Zimmerman, Iowa State University, asks "Are we ready for the next emergent disease?". While the swine industry is extremely efficient, Dr. Zimmerman believes there are vulnerabilities to the admission of diseases.
Transgenic Pigs in PRRSV Research Dr. Randy Prather, University of Missouri, talks about the idea of genetic engineering of pigs for PRRSV resistance. Dr. Prather shows the approaches to the development of the SIGLEC1 pigs that uses Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) to make CRISPR Bacon. Dr. Prather says some in vitro resistance to PRRSv infection has been identified but that challenge studies need to be done.
PRRSV at Herd Level Dr. Bob Rowland, Kansas State University, talks about the analysis of PRRSV immunity at the herd level. Dr. Rowland highlights the system of PRRSV within a nursery and how persistent it is. Dr. Rowland also provides background on the challenges to developing vaccines to PRRSV. In conclusion, Dr. Rowland says neutralizing antibodies participates in the control and clearance of PRRSV and that not all neutralizing antibodies are equal, responses can be divided into distinct groups.
Koch’s Postulates Fulfilled Dr. Dick Hesse, Kansas State University, shares the background of the discovery of the deltacoronavirus. While not a prominent as PEDv, deltacoronavirus is a pathogen and is out there, having been reported in at least 22 US states with continued reports being filled. Dr. Hesse says there still are many gaps in the understanding of deltacoronavirus, including biological and physical transmission.
Genetics of Pigs Dr. Jack Dekkers, Iowa State University, asks the question "Can the genetics of host pig be used to as part of an integrated strategy to control PRRS?" Dr. Dekkers outlines the current research and what approaches are being developed. Genetic selection for improved host response to PRRSv appears possible and can be an important component in the fight against PRRS.
What Is Reverse Genetics In PRRSV? Dr. Jay Calvert, Zoetis, talks about reverse genetics and how that is applied to understanding PRRS and PRRSV infectious cDNA clones. Dr. Calvert provides background on the science and tools that are applied to reverse genetics. Dr. Calvert closes with suggestions on how infectious clones can be used in the future.